MULTI-EXPONENTIAL MODEL TO DESCRIBE PRESSURE-DEPENDENT P- AND S-WAVE VELOCITIES AND ITS USE TO ESTIMATE THE CRACK ASPECT RATIO

We present new quantitative model describing the pressure dependence of acoustic P- and S-wave velocities.Assuming that a variety of individual mechanisms or defects (such as cracks, pore collapse and grain crushing) can contribute to the pressure-dependent change of the wave velocity, we order a characteristic pressure to all of them and allow a s

Introduction: EGFR exon 20 insertion mutations account for 10% of all EGFR mutations and are mostly insensitive to approved EGFR tyrosine kinase inhibitors (EGFR TKIs).Novel EGFR TKIs have been developed or repurposed for these mutants.A limited number of preclinical studies have detailed these EGFR TKIs.We sought to use commercially available mobo